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Association between IL-6 -174 G/C (rs1800795) and IL-1A -889 C/T (rs1800587) cytokine variants with polycystic ovary syndrome in Iranian women: A case-control study

 

Abstract

Background and Aim

 

Infertility in women has various causes, one of which is ovulation disorders. Polycystic ovary syndrome (PCOS) affecting ovulation is a complex idiopathic disease in which genetic polymorphisms may be involved. This study aimed to investigate the relationship between IL-6 -174 G/C and IL-1A -889 G/A cytokine polymorphisms with polycystic ovary syndrome in a population of Iranian women

 

link: https://www.sciencedirect.com/science/article/abs/pii/S037811192400787X?via%3Dihub

 

Unanticipated recurrence of muscle-invasive bladder cancer: A case report

 

ABSTRACT

Muscle-invasive bladder cancer management often involves radical cystectomy, but bladder preservation protocols have gained recognition as a low-morbidity alternative for the management of carefully selected patients. However, close follow-up is crucial for prompt diagnosis of cancer recurrence. We report a case of muscleinvasive bladder cancer managed using a bladder preservation approach. Although cystoscopy and random biopsy findings appeared unremarkable during follow-up, tumor recurrence occurred in the muscular propria without involving the bladder mucosa. This case underscores the importance of revising follow-up protocols to ensure optimal patient care

 

link:https://www.sciencedirect.com/science/article/pii/S2666621925000092

Bilateral testicular mass in a 21-year-old male with a history of congenital adrenal hyperplasia: A case report

 

ABSTRACT

A 21-year-old man was referred because of bilateral testicular swelling from 8 months ago. He had a known history of congenital adrenal hyperplasia (21-hydroxylase deficiency) diagnosed in infancy, managed with glucocorticoid therapy since childhood. However, the patient had been non-adherent to medication for several years. The patient underwent surgery with an inguinal incision, and a biopsy from the mass was sent for frozen section. The frozen and permanent sections were consistent with “Testicular adrenal rest tumor (tumor of adrenogenital syndrome)

 

link:https://www.sciencedirect.com/science/article/pii/S221444202500035X

Left atrial appendage velocity, association with inflammatory indices in non-valvular atrial fibrillation patients

 

Abstract

Introduction: Decreased left atrial appendage emptying velocity (LAAV) is a marker for thrombus formation. This study evaluates the association between LAAV and inflammatory indices in non-valvular atrial fibrillation (AF) patients.

Methods: The study population was 1428 patients with AF, 875 of whom enrolled. Based on the LAAV, patients were divided into three groups of 262 patients with a velocity of <25 cm/s, 360 patients with a velocity of 25 to 55 cm/s, and 253 patients with a velocity of >55 cm/s to assess and compare in terms of inflammatory indices, including the platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, systemic immune inflammation index, neutrophil - to - platelet ratio and white blood cell-to-platelet ratio (WPR).

 

link:https://pubmed.ncbi.nlm.nih.gov/39874020

Effectiveness of the Continuous Care Model on Quality of Life, Sexual Satisfaction and Function in Bladder Cancer Patients Undergoing Tumor Resection Surgery: A randomized control trial

 

Abstract

Background

Bladder cancer is a global health concern, and while surgery is vital, it often diminishes patient quality of life, notably sexual function. Existing self-care education is insufficient, necessitating a more holistic approach. The Continuous Care Model (CCM), which emphasizes patient empowerment, shows promise. This study
investigates a CCM intervention that includes sexual health education to improve quality of life (QoL) and sexual satisfaction in bladder cancer patients
 
 

A Review on Radiologic Hot Cross Bun Sign and Related Clinical Conditions

Abstract

The hot cross bun (HCB) sign is a cruciform-shaped hyperintensity on axial T2 weighted-image magnetic resonance imaging (MRI), mostly reported with multiple system atrophy (MSA). However, several other diagnoses were reported with this radiologic manifestation as well. This review investigates the wide spectrum of disorders in which the HCB sign has been reported as a positive radiologic manifestation. This narrative review was conducted using the PubMed database. Studies reporting the HCB sign in their manuscript are included in this manuscript. 83 studies with available full text met the inclusion criteria for this review. The total number of reported patients with HCB sign is addressed in the manuscript. In addition to MSA, the HCB sign has been reported in various other disorders, including spinocerebellar ataxia, malignancies, infections, autoimmune disorders, and some vascular and ischemic changes. Any disorder involving the pontocerebellar fibers can manifest the HCB sign following the gliosis changes or infarction-mediated damage to the region, whether due to gliosis changes. The range of diseases linked to the HCB sign is broader than previously recognized, as numerous disorders affect the transverse pontocerebellar fibers and cause radiologic HCB manifestation. MSA remains the most common condition; however, clinicians should consider alternate differential diagnoses in patients displaying the HCB sign in whom clinical presentation is not typical of MSA.

Keywords: Hot cross bun sign; Multiple system atrophy; Neurology; Radiology; Spinocerebellar ataxia

link: https://pubmed.ncbi.nlm.nih.gov/40117078

 

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